San Blas is today a downtown neighborhood in the city known as the " Artists' District", with narrow and writhing streets, most of them steep. In Incan times it was one of the most important districts of Qosqo and its name was "T'oqo-kachi" (T'oqo = hollow; kachi = salt). Like the other districts it was inhabited by the Quechua nobility. It seems that the church was erected over an Incan Sanctuary devoted to cult of the "Illapa" god (Thunder, Lightning and Thunderbolt). It was possibly opened for the first time in 1544 by the city's second Bishop Juan Solano. Although some other versions say that it was after 1559 as consequence of viceroy Andres Hurtado de Mendoza's order by which "Indians" had to built churches for their indoctrination in the districts where they lived. Its structure was simple with a rectangular floor plan and mud brick walls, but after the earthquakes in 1650 and 1950 it was partially reinforced with stone walls. It has just one nave and two gates before which there are big plazas; and a stone bell tower constructed after the 1950 earthquake instead of the original made with mud bricks.

Inside the church is one of the greatest jewels of colonial art in the continent: the Pulpit of Saint Blaise; which is a filigree made in cedar wood by expert hands managing a gouge. It is not known with certainty who was the artist or artists that made it, how long the work lasted, neither any other details about it. However, the pulpit is over there as a mute witness of a great Catholic devotion and devoted work. There are enough proofs to assert that it was made carved with funds given by art protector Bishop Manuel Mollinedo y Angulo; therefore, it was by the end of the XVII century. There are serious discrepancies about the identity of the performing artist.

Most authors suggest that it was made by the most famous Quechua woodcarver: Juan Tomas Tuyro Tupaq, that was contemporary and protected of Mollinedo y Angulo, who entrusted him the manufacture of several works. It also could have been work of some other artists contemporary with Mollinedo such as Martin de Torres, Diego Martinez de Oviedo who made the monumental High Altar of the Compañia de Jesus Church, or the Franciscan Luis Montes that made the San Francisco Church's choir. Oral tradition has its version gathered by Angel Carreño who in his "Cusquenian Traditions" manuscript had stated in writing the name Esteban Orcasitas as the pulpit's author; but, for the 1st. edition of his book the name was changed by that of Juan Tomas Tuyrutupa. Tuyrutupa was Quechua and Cusquenian, but according to that traditional version he was a leper woodcarver from Huamanga (Ayacucho). The story tells that once he had in his dreams a revelation of the "Holy Virgin of the Good Happening" who told him that if he wanted to get healed from his leprosy he had to look for her in the small plaza of Arrayanpata in Qosqo City. After a long journey and many mishaps, one day he found her painted on a wall after that the roofing of the "Lirpuy-Phaqcha" chapel fell in. Falling on his knees and weeping he invoked her, as the Virgin's rosary became rose petals with which he rubbed hard his whole body remaining thus completely healed. The piece of wall containing the painting was cut and moved to the Saint Blaise Church, then people agreed upon to build an altarpiece and a pulpit for the Virgin. The grateful Quechua woodcarver committed himself to make the pulpit without charging any money for the work estimated in 1400 pesos. The work took him 4 years of hard labor with wood from an enormous cedar tree that was cut in the Kusipata square (present-day Regocijo). But, when finishing his work the woodcarver failed his oath as he asked the church's curate for 70 pesos in order to lionize a Cusquenian half-breed woman. After fastening the Saint Paul statue over the pulpit's sounding board, he stumbled and fell off dying soon after. His corpse was buried under the pulpit but some time later it was taken out and his skull placed before the feet of the Saint Paul sculpture, where it is seen today.

As any other normal pulpit, that of Saint Blaise has a balcony (basin), a thorax (main body), a sounding board (cupola), and a gallery (entrance). The Basin is spherical and supported by a bronze structure; it contains eight human busts representing the Catholicism heretics